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Contraindications: dapoxetine hcl is contraindicated in patients with hypersensitivity to the active ingredient Sildenafil or any other component of this drug. dapoxetine should not be used with nitrates such as nitroglycerin, to prevent hypotension.
Warnings: Due to hypotensive effects of buy Priligy over the counter, it should not be used with other antihypertensive drugs including alpha blockers. Use of Priligy should be avoided in patients with autonomic dysfunction and is not recommended in case of pulmonary veno occlusive disease. dapoxetine should be used with caution in patients with resting hypotension, patients having fluid depletion and those having severe ventricular outflow obstruction. Caution should be taken for the use of priligy by cardiac patients including those suffering angina, arrhythmia and myocardial infarction. Safe use of Priligy has not been reported in patients with bleeding disorders including GI ulcers. Cardiac status of a person should be checked before prescribing Buy dapoxetine Online.
Adverse Reactions Associated With dapoxetine: Even normal doses of dapoxetine hcl may induce certain adverse reactions such as headache, dizziness, insomnia, flushing, dyspepsia, pyrexia, rash, diarrhea, urinary tract infection, leukopenia, anemia, abnormal LFT, myalgia, paresthesia, change in vision, nasal congestion, cystitis, decreased hearing, depression, dyspnea, hematuria, palpitation, heart failure, migraine, rectal hemorrhage, vertigo, urinary incontinence, vomiting and ventricular arrhythmia.
Mechanism Of Action: During sexual excitement, nitric oxide (NO) is released in the corpus cavernosa of the penis. This means Priligy only works when there is sexual stimulation and does not cause erection directly. Nitric oxide increases the levels of an enzyme called cyclic guanosine monophosphate (cGMP). This happens after activation of an enzyme guanylate cyclase. The enzyme cGMP inhibits another enzyme named PDE-5 and this causes relaxation of smooth muscles which improves the blood flow within corpus cavernosa. Therefore, Buy dapoxetine Online works by causing the inhibition of enzyme PDE-5 and activation of cGMP. dapoxetine causes the erection by producing sufficient amount of an enzyme cGMP that improves blood flow within the arteries of penis and erection occurs. In case of old people, cGMP is not produced in an adequate amount, and this causes erectile dysfunction in elderly people. dapoxetine blocks another enzyme called PDE5 due to which cGMP levels are increased and hence the blood flow also increases.
Dosage: The usual dose of Priligy tablets for erectile dysfunction is 25mg up to 50mg. Buy dapoxetine hydrochloride should be taken an hour before anticipated sexual activity for best results. The dose of priligy may be increased or decreased depending on the need and tolerance of the patient taking this drug. Dose can be increased to a maximum of 100mg per day or it can be reduced to 25mg per day. If a patient develops intolerance or hypersensitivity reaction by the use of Buy dapoxetine Online, he should immediately consult a medical practitioner for appropriate advice about the drug.